- AGOSTINO TINACCI (? -1367), the Bishop of Narni
- FABIANO CIOCCO DI MONTE (1421-1498), jurist, the first who assumed the surname "Di Monte"
- MARIOTTO DI MONTE (? - 1493), leader
- DOMENICO GALLETTI (1443/44-1501), writer
- ANTONIO DI MONTE (1462-1533), Cardinal of Santa Prassede, papal legate.
- ANDREA SANSOVINO (1467 ca. - 1529), sculptor and architect.
- VINCENZO DI MONTE (1468 ca. - 1504 approx.), Jurist.
- NICCOLO SOGGI (1479? -1552), painter and architect.
- CRISTOFORO GUIDALOTTI DI MONTE (Arezzo 1484-1564), Cardinal of Santa Prassede (known as the "cardinal of Marseille").
- BALDUINO DI MONTE (Rome 1485-1556), First Count of Monte San Savino.
- GIOVANNI MARIA DI MONTE (Rome 1487-1555), Pope Julius III (1550-55).
- PIETRO GUIDALOTTI DI MONTE (1495 or 1496-1572), Grand Master of the Order of Malta.
- GIULIO GALLETTI (1499 ca.-1563), the bishop of Alessano.
- GASPERO DI MONTE (? -1545),the bishop of Civitate.
- GIOVANNI GIOCCHI (? -1554), the bishop of Cagli.
- ANTONIO MENICUCCI (? -1557), the bishop of Minori and Nepi and Sutri.
- GABRIELLO DI MONTE (1534-1597), the bishop of Jesi.
- STEFANO VELTRONI (XVI century), painter.
- FRANCESCO CONTRINI (XVI century), poet.
- JACOPO TORRICELLI, the bishop of Marseilles (1605).
- PIETRO PETRI (? -1580), the bishop of Lucera.
- ASCANIO DELLA CORNIA (Perugia 1516-1571), leader.
- COSTANTINO VELTRONI (1516-1585), the bishop of Scala and Cortona.
- GIOVAN BATTISTA DI MONTE (1518-1552), General.
- INNOCENZO DI MONTE (1532-1577), Cardinal of Sant 'Onofrio.
- JACOPO GALLETTI (? -1574), the bishop of Alessano.
- ACCURSIO BALDI (? -1607), Sculptor and engraver.
- ORAZIO PORTA (1540 ca.-1615 ca.), Painter, architect.
- FABIANO DI MONTE (c. 1545 1569), second Count of Monte San Savino.
- FABIANO FIOGHI (before 1550-1620 ca.), Ebraicista.
- GIULIO MATTEI (? -1623), the bishop of Bitetto.
- FRANCESCO PIFFERI (ca. 1550-after 1604), monaco Camaldolese scientist.
- ULISSE GIOCCHI (after 1560-1631), painter.
- BARTOLOMEO VELTRONI (XVI century), knight of Malta.
- GIOVANNI MATTEI, the bishop of Castellaneta (1595).
- BALDOVINO DI MONTE SIMONCELLI (Orvieto in 1582? -1629), Writer and poet.
- SALLUSTIO BARTOLI (1586 -?), the bishop of Stroud.
- BERNARDO GUGLIELMI (1588-1623), man of letters.
- CAMMILLO BALDI (? -1649), the bishop of Nicotera and Acquapendente.
- FLAVIO GALLETTI (? -1653), the bishop of Anglona.
- VITALE PERINI (XVII), monaco Camaldolese and architect.
- VINCENZO MARIA VELTRONI (seventeenth century), writer.
- MINOZZI PIER FRANCESCO (1611-1672), jurist, poet and man of letters.
- GIOVAN BATTISTA CAPALLI (1623-1695), dean of the cathedral of Arezzo, writer and academic.
- DOMENICO SOZZINIi (1630 -?), painter.
- GIOVAN BATTISTA CUNGI (1647-1712), general of the Venetian Republic.
- REMIGIO BUCCI, general camaldolese (1649).
- ANTON LEONE RESTORELLI (1704-1786), first dean of Monte San Savino, local chronicler.
- ALESSANDRO GALLETTI (1710-1782), the bishop of Volterra.
- RESTORELLO RESTORELLI (1720 ca.-1800 ca.), priest and chronicler local.
- GIUSEPPE GALLETTI (1738 -?), Doctor.
- SALOMON FIORENTINO (1743-1815), poet.
- FILIPPO CARRESI (Massa Marittima 1791-1849), surgeon.
- FERDINANDO ZANNETTI (1801-1881), physician, scientist and patriot.
- GIULIO SALVADORI (1862-1928), writer, poet and teacher.
- GIUSEPPE SANARELLI (1864-1940), physician, scientist and senator of the kingdom.
- ZULIMO ARETINI (1884-1965), ceramicist.
- CIRO GIROLAMI (1888 -?), Art critic.
- BENITO MUSSOLINI (Dovia of Predappio, 1883 - Giulino Mezzegra 1945), politician and honorary citizen of Monte San Savino (of Civil Law. 169 of 21 May 1924);
- DOMENICO BARCHIELLI (Gubbio 1858 -?), Educator and honorary citizen of Monte San Savino (of Civil Law. 332 of 2 March 1927);
- CECILIA GASDIA(Verona 1960), opera singer and honorary citizen of Monte San Savino (of Civil Law. 200 of 29 August 1982);
- GIOVANNI COLOMBO (Caronno Pertusella 1902 - Milan 1992), Archbishop of Milan and honorary citizen of Monte San Savino (of Civil Law. 131 of 25 May 1986);
- ELIO TOAFF (Livorno 1915), emeritus chief rabbi of the Jewish community of Rome and honorary citizen of Monte San Savino (of Civil Law. 2 of 19 February 1995).
